Acetyl L-Carnitine is structurally similar to acetylcholine and may help facilitate its production and maintenance of optimal levels. Acetylcholine is involved in supporting memory, focus, and learning. It also serves to regulate activities of vital organs and blood vessels, as well as communication between nerves and muscles. ALC can help support the repair of cells in the brain and nervous system that have been damaged by stress and poor diet.*
L-Carnitine, (not the ALC form) is required to help escort fats into the part of the cell where they are burned and converted into energy (the mitochondria), thereby supporting energy production and weight management. Acetyl L-Carnitine works differently. Because the unique “acetyl” molecule allows this compound to work differently in the body, ALC may support energy production within brain cells, aiding in mental clarity, focus, and stamina.
The neurotransmitter acetylcholine is important for a healthy, balanced mood. Acetyl L-carnitine not only supports a healthy mood by encouraging normal acetylcholine levels, but also by supporting energy production and delivery to brain cells. Energized brain cells communicate better with each other and with the rest of the body, leading to a healthier mood.*
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Dowson JH, Wilton-Cox H, Cairns MR, Ramacci MT. The morphology of lipopigment in rat Purkinje neurons after chronic acetyl-L-carnitine administration: a reduction in aging-related changes. Biol Psychiatry 1992; 32:179-87.
- Cipolli C, Chiari G. [Effects of L-acetylcarnitine on mental deterioration in the aged: initial results]. Clin Ter 1990; 132:479-510.
- Guarnaschelli C, Fugazza G, Pistarini C. Pathological brain ageing: evaluation of the efficacy of a pharmacological aid. Drugs Exp Clin Res 1988; 14:715-8.
- Tempesta E, Troncon R, Janiri L, et al. Role of acetyl-L-carnitine in the treatment of cognitive deficit in chronic alcoholism. Int J Clin Pharmacol Res 1990; 10:101-7
- Ferreira, G. C., & McKenna, M. C. (2017). L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochemical research, 42(6), 1661–1675. doi:10.1007/s11064-017-2288-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621476/
- Wang, S.-M., Han, C., Lee, S.-J., Patkar, A. A., Masand, P. S., & Pae, C.-U. (2014). A review of current evidence for acetyl-l-carnitine in the treatment of depression. Journal of Psychiatric Research, 53, 30–37. doi:10.1016/j.jpsychires.2014.02.005 https://www.ncbi.nlm.nih.gov/pubmed/24607292
- Veronese, N., Stubbs, B., Solmi, M., Ajnakina, O., Carvalho, A. F., & Maggi, S. (2018). Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms. Psychosomatic Medicine, 80(2), 154–159. doi:10.1097/psy.0000000000000537 https://www.ncbi.nlm.nih.gov/pubmed/29076953
- Patti F, Marano P, Cappello S. Effects of L-Acetylcarnitine on functional recovery of hemiplegic patients. Clin Trials J 1988; 25:87-101.
- Brooks JO, 3rd, Yesavage JA, Carta A, Bravi D. Acetyl L-carnitine slows decline in younger patients with Alzheimer’s disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. Int Psychogeriatr 1998; 10:193-203.
- Rai G, Wright G, Scott L, Beston B, Rest J, Exton-Smith AN. Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer’s dementia. Curr Med Res Opin 1990; 11:638-47.
- Thal LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer’s disease. Neurology 1996; 47:705-11.
- Sano M, Bell K, Cote L, et al. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer’s disease. Arch Neurol 1992; 49:1137-41.
- Spagnoli A, Lucca U, Menasce G, et al. Long-term acetyl-L-carnitine treatment in Alzheimer’s disease. Neurology 1991; 41:1726-32.
- Puca FM, Genco S, Specchio LM, et al. Clinical pharmacodynamics of acetyl-L-carnitine in patients with Parkinson’s disease. Int J Clin Pharmacol Res 1990; 10:139-43.
- Kobayashi, S., Iwamoto, M., Kon, K., Waki, H., Ando, S., & Tanaka, Y. (2010). Acetyl-l-carnitine improves aged brain function. Geriatrics & Gerontology International, 10, S99–S106. doi:10.1111/j.1447-0594.2010.00595.x https://www.ncbi.nlm.nih.gov/pubmed/20590847
- De Angelis C, Scarfo C, Falcinelli M, et al. Acetyl-L-carnitine prevents age-dependent structural alterations in rat peripheral nerves and promotes regeneration following sciatic nerve injury in young and senescent rats. Exp Neurol 1994; 128:103-14.
- De Angelis C, Scarfo C, Falcinelli M, Reda E, Ramacci MT, Angelucci L. Levocarnitine acetyl stimulates peripheral nerve regeneration and neuromuscular junction remodelling following sciatic nerve injury. Int J Clin Pharmacol Res 1992; 12:269-79.
- Sergi, G., Pizzato, S., Piovesan, F., Trevisan, C., Veronese, N., & Manzato, E. (2017). Effects of acetyl-l-carnitine in diabetic neuropathy and other geriatric disorders. Aging Clinical and Experimental Research, 30(2), 133–138. doi:10.1007/s40520-017-0770-3 https://www.ncbi.nlm.nih.gov/pubmed/28534301
- Li, S., Chen, X., Li, Q., Du, J., Liu, Z., Peng, Y., … Tian, H. (2016). Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial. Journal of diabetes investigation, 7(5), 777–785. doi:10.1111/jdi.12493 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009142/
- Famularo G, Moretti S, Marcellini S, et al. Acetyl-carnitine deficiency in AIDS patients with neurotoxicity on treatment with antiretroviral nucleoside analogues. Aids 1997; 11:185-90.
- Scarpini E, Sacilotto G, Baron P, Cusini M, Scarlato G. Effect of acetyl-L-carnitine in the treatment of painful peripheral neuropathies in HIV+ patients. J Peripher Nerv Syst 1997; 2:250-2.
- Agarwal A, Sengupta P, Durairajanayagam D. Role of L-carnitine in female infertility. Reprod Biol Endocrinol. 2018 Jan 26;16(1):5. doi: 10.1186/s12958-018-0323-4. PubMed PMID: 29373970; PubMed Central PMCID: PMC5785901. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785901/
- Jirillo E, Altamura M, Munno I, et al. Effects of acetyl-L-carnitine oral administration on lymphocyte antibacterial activity and TNF-alpha levels in patients with active pulmonary tuberculosis. A randomized double blind versus placebo study. Immunopharmacol Immunotoxicol 1991; 13:135-46.
- Singh, S., Mishra, A., Srivastava, N., Shukla, R., & Shukla, S. (2016). Acetyl-l-Carnitine via Upregulating Dopamine D1 Receptor and Attenuating Microglial Activation Prevents Neuronal Loss and Improves Memory Functions in Parkinsonian Rats. Molecular Neurobiology, 55(1), 583–602. doi:10.1007/s12035-016-0293-5 https://www.ncbi.nlm.nih.gov/pubmed/27975173
- Evans, J. D., Jacobs, T. F., & Evans, E. W. (2008). Role of Acetyl-L-Carnitine in the Treatment of Diabetic Peripheral Neuropathy. Annals of Pharmacotherapy, 42(11), 1686–1691.doi:10.1345/aph.1l201 https://www.ncbi.nlm.nih.gov/pubmed/18940920
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