Bio Flora

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This product is a spore-based, broad-spectrum probiotic formula designed to promote a healthy gut microflora, protect mucosal integrity, and relieve small intestinal bacterial overgrowth (SIBO). Each capsule provides key Bacillus spore- forming probiotic strains that remain in a dormant protective state in the harsh gastrointestinal environment yet become active on target to colonize and recondition the gut. Uniquely included in this formula are serum-derived bovine immunoglobulins that bind to microbes and toxins that are common in SIBO, for elimination.

BENEFITS

  • Helps Maintain Normal Gastrointestinal Balance
  • Provides Concentrated Immunoglobulins to Enhance Mucosal Immunity
  • Supports Digestion and Micronutrient Absorption
  • Maintains GI Barrier Health and Integrity

Dosage
3 capsules per day or as recommended by your health care professional.

Does Not Contain
Wheat, gluten, soy, corn, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners or preservatives.

Caution
If you are pregnant or nursing, consult your physician before taking this product.

Sign and Symptoms of Small Intestinal Bacterial Overgrowth
Sign and Symptoms of Small Intestinal Bacterial Overgrowth

Description

SIBO is a condition that occurs when there is an overabundance of commensal bacteria from the colon present in the small intestine. SIBO is largely overlooked and more prevalent than previously thought.1 The health of the small intestines relies on balanced microbiota, and probiotics and immunoglobulins can contribute to that balance by having a positive influence on the intestinal environment, including pH, organism diversity, and immune signaling. SIBO remains an area of research, but it is understood that dysbiosis and motility are key components. Such dysbiosis of the small intestine can be attributable to low stomach acid, medications, or alcohol consumption.2

Probiotics have been extensively studied and are characterized as having broad GI and immune benefits, including increasing the population of healthy bacteria following microflora imbalance; supporting healthy bowel function; increasing the production of short-chain fatty acids, which provide energy to the cells of the intestinal lining; strengthening the gut-immune barrier by promoting a healthy gut mucosa; aiding in the digestion of compounds like lactose and casein; and enhancing detoxification of harmful compounds.

Probiotics are live organisms and must be shelf stable through the expiration date, so they can be precisely delivered to the intestinal tract to have maximum benefit. Bacillus spores can transition between a dormant and an active form, depending on the environment. Bacillus spores remain dormant in harsh environments until they reach more favorable environments like the human gastrointestinal tract. In its dormant spore form, Bacillus surrounds itself with an endospore, which is a tough, natural outer shell that protects it from light, heat, pressure, acid, lack of oxygen, and other environmental factors. Bacillus changes into its active form in the large intestine to colonize the gut to encourage microbial diversity of commensal gut bacteria. In its active form, Bacillus can increase microbial diversity by changing the pH, and increasing the production of short-chain fatty acids. The combination of specific strains, particularly Bacillus coagulans, Bacillus clausii, and Bacillus subtilis, relieve symptoms for common GI complaints and reinforce healthy gut function.3

The discovery that the gut barrier plays a key role in immune health fueled the search to strengthen it. Research has shown that the binding capabilities of immunoglobulins have a positive effect on gut barrier function.4 In the search for innovative ways to improve microbiome diversity, we have combined our blend of spore-forming probiotics alongside immunoglobulins uniquely shown to bind to bacteria and toxins, driving immune response. IgG helps to maintain a healthy intestinal immune system by binding a broad range of microbes and toxins within the gut lumen. As these unwanted triggers are removed, it resets healthy immune tolerance and builds a stronger barrier to the external environment in the gut. Serum-derived bovine immunoglobulins have the highest IgG concentration available for GI and immune challenges where allergens are a significant concern.

Ingredients

Bacillus coagulans

Bacillus coagulans has been shown to increase the commensal GI microbiota. Supplementation of 1 billion CFU daily for 28 days with B. coagulans significantly increased levels of the commensal microbe F. prausnitzii from baseline compared to placebo, as well as increased Bacillus spp. in fecal samples of adults over 65.5 Bacillus coagulans has also been shown to relieve GI discomfort and improve stool consistency. Bacillus coagulans given once a day for eight weeks showed reduced daily bowel movements and GI symptoms.6 B. coagulans also significantly improved bowel movements in healthy adults with occasional constipation, as well as decreased abdominal discomfort.7

Bacillus clausii

B. clausii is commonly used as a probiotic to promote balance in the microbiome and has showed promising results in individuals with SIBO specifically.8 B. clausii has demonstrated significant effectiveness in adults with acute diarrhea.9 B. clausii has also shown to significantly reduce duration of occasional diarrhea and decreased stool frequency in children.10

Bacillus subtilis

Bacillus subtilis has been shown to relieve GI distress in patients. Bacillus subtilis supplementation of 1-3 billion CFU alongside motility stimulating agents was shown effective for relief of GI symptoms at four weeks .11

Serum-derived bovine immunoglobulins

Probiotics are a natural choice for supporting beneficial bacteria in the gut, but supplementation to eliminate unwanted microbes should also be considered. Within the gut barrier, researchers found that the binding capabilities of immunoglobulins have a positive effect on gut barrier function in vitro.4 Broad-spectrum binding capabilities (See Table 1) demonstrate the positive influence of serum-derived bovine immunoglobulins.4 This binding and elimination decreases microbe and toxin encounters by the immune system and resets immune tolerance.12,13

References

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

1. Dukowicz AC, Lacy BE, Levine GM. Small intestinal bacterial overgrowth: a comprehensive review. Gastroenterol Hepatol (N Y). 2007 Feb;3(2):112-22. PMID: 21960820; PMCID: PMC3099351.
2. Bures J, Cyrany J, Kohoutova D, Förstl M, Rejchrt S, Kvetina J, Vorisek V, Kopacova M. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol. 2010 Jun 28;16(24):2978-90. doi: 10.3748/wjg.v16.i24.2978. PMID: 20572300; PMCID: PMC2890937.
3. Soman RJ, Swamy MV. A prospective, randomized, double- blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of SNZ TriBac, a three-strain Bacillus probiotic blend for undiagnosed gastrointestinal discomfort. Int J Colorectal Dis. 2019;34(11):1971-1978. doi:10.1007/s00384-019-03416-w
4. Detzel CJ, Horgan A, Henderson AL, et al. Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model. PLoS One. 2015;10(4):e0120278. Published 2015 Apr 1. doi:10.1371/ journal.pone.0120278
5. Nyangale EP, Farmer S, Cash HA, Keller D, Chernoff D, Gibson GR. Bacillus coagulans GBI-30, 6086 Modulates Faecalibacterium prausnitzii in Older Men and Women. J Nutr. 2015;145(7):1446-1452. doi:10.3945/jn.114.199802
6. Dolin BJ. Effects of a proprietary Bacillus coagulans preparation on symptoms of diarrhea-predominant irritable bowel syndrome. Methods Find Exp Clin Pharmacol. 2009;31(10):655-659. doi:10.1358/mf.2009.31.10.1441078
7. Madempudi RS, Neelamraju J, Ahire JJ, Gupta SK, Shukla VK. Bacillus coagulans Unique IS2 in Constipation: A Double- Blind, Placebo-Controlled Study. Probiotics Antimicrob Proteins. 2020;12(2):335-342. doi:10.1007/s12602-019- 09542-9
8. Gabrielli M, Lauritano EC, Scarpellini E, Lupascu A, Ojetti V, Gasbarrini G, Silveri NG, Gasbarrini A. Bacillus clausii as a treatment of small intestinal bacterial overgrowth. Am J Gastroenterol. 2009 May;104(5):1327-8. doi: 10.1038/ ajg.2009.91. Epub 2009 Apr 7. PMID: 19352343.
9. Sudha MR, Bhonagiri S, Kumar MA. Efficacy of Bacillus clausii strain UBBC-07 in the treatment of patients suffering from acute diarrhoea. Benef Microbes. 2013 Jun 1;4(2):211-6. doi: 10.3920/BM2012.0034. PMID: 23443952.
10. Ianiro G, Rizzatti G, Plomer M, et al. Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2018;10(8):1074. Published 2018 Aug 12. doi:10.3390/nu10081074
11. Choi CH, Kwon JG, Kim SK, et al. Efficacy of combination therapy with probiotics and mosapride in patients with IBS without diarrhea: a randomized, double-blind, placebo- controlled, multicenter, phase II trial [published correction appears in Neurogastroenterol Motil. 2015 Nov;27(11):1684- 5. Dosage error in article text]. Neurogastroenterol Motil. 2015;27(5):705-716. doi:10.1111/nmo.12544
12. Jasion VS, Burnett BP. Survival and digestibility of orally- administered immunoglobulin preparations containing IgG through the gastrointestinal tract in humans. Nutr J. 2015;14:22. Published 2015 Mar 7. doi:10.1186/s12937- 015-0010-7
13. Petschow BW, Burnett B, Shaw AL, Weaver EM, Klein GL. Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy. Clin Exp Gastroenterol. 2014;7:181-190. Published 2014 May 24. doi:10.2147/CEG.S62823

Warnings

Always be sure to speak with your healthcare provider before starting any new nutritional supplement when pregnant or nursing. For children, we recommend speaking with your child's pediatrician regarding proper dosing. Store away from children.

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