Every day, the liver is bombarded with a vast array of chemicals it needs to sort through, store and remove. Since the liver is of utmost importance to a body’s ability to detoxify, it’s important to make sure it is functioning as it should.
Since the liver can easily get overworked from the vast number of chemicals its subjected to every day, liver support should be introduced into any protocol.
Three of our favorite herbal combinations for supporting the liver are featured in Liver Support Liquid. It contains silymarin and Oregon grape root, two herbs famous for supporting liver function. It also contains yellow dock, which aids patients in emptying their bowels.
Silymarin, the main bioflavonoid found in milk thistle seeds, is one of the oldest, safest, most well-known liver-supporting herbs. It enhances detoxification pathways and improves bile movement, along with supporting the gallbladder, kidneys, and spleen. It protects the liver from medications, environmental contaminants, and other harmful chemicals.
Silymarin increases phase II enzyme activity in the liver and prevents glutathione from decreasing inside liver cells. This protects the cells from free radical activity and enhances detoxification. Some of the many ways silymarin protects the liver are with its antioxidant properties, by preventing lipid oxidation and balancing phase I detoxification.
Oregon grape root is native to the Pacific Northwest and, despite its name, isn’t a grape at all. It’s actually a part of the evergreen family. However, like grapes, it directly supports blood health with its antioxidant properties that promote improved blood flow throughout the body. Thanks to its positive effects on the blood supply, it improves liver function by enhancing blood flow to the liver, which helps the liver function well.
Oregon grape root has traditionally been used to promote detoxification. Not only does it have liver-boosting properties, but it also improves gallbladder function and encourages the healthy production of enzymes from the pancreas and intestines.
Yellow dock is another ingredient featured in Liver Support Liquid. It helps the gallbladder system more directly (even if you don’t have a gallbladder your cystic ducts are still here!), which promotes your body’s ability to empty the bowels. One of the most important purposes of defecating is to remove toxins from the body. If the bowels can’t evacuate feces effectively, the toxins get reabsorbed and the liver has to repeat the work it already did. That can easily lead to an overwhelmed liver. Yellow dock supports this function, which ultimately helps prevent the liver from having to overwork.
- Wagner H. Plant constituents with antihepatotoxic activity. In: Beal JL, Reinhard E eds. Natural Products as Medicinal Agents. Stuttgart: Hippokrates-Verlag; 1981.
- Bosisio E, Benelli C, Pirola O, et al. Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. Pharmacol Res 1992;25:147-154.
- Baer-Dubowska W, Szaefer H, Drajka-Kuzniak V. Inhibition of murine hepatic cytochrome P450 activities by natural and synthetic phenolic compounds. Xenobiotica 1998;28:735-743.
- Halim AB, el-Ahmady O, Hassab-Allah S, et al. Biochemical effect of antioxidants on lipids and liver function in experimentally-induced liver damage. Ann Clin Biochem 1997;34:656-663.
- Campos R, Garido A, Guerra R, et al. Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Med 1989;55:417-419.
- Fiebrich F, Koch H. Silymarin, an inhibitor of lipoxygenase. Experentia 1979;35:150-152.
- Fantozzi R, Brunelleschi S, Rubino A, et al. FMLP-activated neutrophils evoke histamine release from mast cells. Agents Actions 1986;18:155-158.
- Dehmlow C, Murawski N, de Groot H, et al. Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells. Life Sci 1996;58:1591-1600.
- De La Puerta R, Martinez E, Bravo L. Effect of silymarin on different acute inflammation models and on leukocyte migration. J Pharm Pharmacol 1996;48:968-970.
- Sonnenbichler J, Zetl I. Biochemical effects of the flavanolignane silibinin on RNA, protein and DNA synthesis in rat livers. In: Cody V, Middleton E, Harbourne JB, eds. Plant Flavonoids in Biology and Medicine: Biochemical, Pharmacological, and Structure-Activity Relationships. New York, NY; 1986:319-331.
- Deak G, Muzes G, Lang I. Immunomodulator effect of silymarin therapy in chronic alcoholic liver diseases. Orv Hetil 1990:131:1291-1292, 1295-1296. [Article in Hungarian].
- Lang I, Nekam K, Gonzalez-Cabello R. Hepatoprotective and immunological effects of antioxidant drugs. Tokai J Exp Clin Med 1990;15:123-127.
- Pradhan SC, Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res. 2006 Nov;124(5):491-504. [PMID: 17213517].
- Chtourou Y, Mouldi Garoui E, Boudawara T, Zeghal N. Protective role of silymarin against manganese-induced nephrotoxicity and oxidative stress in rat. Environ Toxicol. 2013 Jan 22. doi: 10.1002/tox.21845. [Epub ahead of print].
- Ninsontia C, Pongjit K, Chaotham C, Chanvorachote P. Silymarin selectively protects human renal cells from cisplatin-induced cell death. Pharm Biol. 2011 Oct;49(10):1082-90. Epub 2011 May 18.
- Kaur G, Athar M, Alam MS. Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumor promotion response. Invest New Drugs. 2010 Oct;28(5):703-13. Epub 2009 Jul 10.
Always be sure to speak with your healthcare provider before starting any new nutritional supplement when pregnant or nursing. For children, we recommend speaking with your child's pediatrician regarding proper dosing. Store away from children.
If loose stools occur, stop use and notify your healthcare practitioner.