Vitamin B9 (folate) has extensive actions in the human body, with research showing it is necessary for a multitude of vital processes, such as supporting DNA synthesis, supporting healthy homocysteine metabolism, nervous system support, promoting energy production, promoting healthy cellular integrity, supporting healthy hormone metabolism, and more.τ2 Unfortunately, the folic acid found in food and many multivitamin supplements needs to go through several enzymatic conversions to be converted to its bioactive form L-5- MTHF. Research suggests that folate can support cardiovascular health by effectively promoting healthy homocysteine levels.τ L-5-MTHF is the preferred form of supplemental vitamin B9 for many people as there are a number of common polymorphisms of folate metabolism, which can lead to imperfections in critical biosynthetic pathways (and ultimately, health complications).3
Research cited herein suggests Biofolate® L-5-MTHF can help support healthy folate status, especially in individuals who don’t properly metabolize folic acid into its biologically active form.
- Scaglione F, Panzavolta G. (2014). Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica.
- Lucock, M. (2000). Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Molecular genetics and metabolism, 71(1), 121-138.
- Blom, H. J., & Smulders, Y. (2011). Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. Journal of inherited metabolic disease, 34(1), 75-81.
Always be sure to speak with your healthcare provider before starting any new nutritional supplement when pregnant or nursing. For children, we recommend speaking with your child's pediatrician regarding proper dosing. Store away from children.
If loose stools occur, stop use and notify your healthcare practitioner.