S. Boulardii

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What is Saccharomyces boulardii?
Saccharomyces boulardii is a health promoting, probiotic yeast. To be an effective probiotic, microorganisms must have certain qualities to withstand the natural defense factors of the host. These include resistance to gastrointestinal transit and the ability to thrive at human core temperatures. Saccharomyces boulardii is a stomach acid-resistant probiotic, proven to survive high temperatures and transit into the intestines. As a probiotic, S. boulardii actively promotes healthy gastrointestinal flora, strengthens intestinal barrier function, and enhances immune function. This formulation is freeze-dried, lactose-free, and strain-verified through genetic typing to ensure maximum efficacy.


  • Balances Gastrointestinal Flora
  • Boosts Immune Function
  • Supports Gastrointestinal Barrier Function and Integrity

1 capsule two times per day or as recommended by your health care professional.

Does Not Contain
Wheat, gluten, soy, corn, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners or preservatives.

If you are pregnant or nursing, consult your physician before taking this product.

Leaky Gut Reinoculate


S. boulardii was first identified in the 1920s by French microbiologist Henri Boulard. Since its discovery, there have been 250 peer-reviewed articles examining S. boulardii, making this one of the most studied probiotics available. S. boulardii is a non-pathogenic yeast and maintains distinct taxonomic and physiological difference from Saccharomyces cerevisiae or “brewer’s yeast.” 1,2 S. boulardii has been shown to support gastrointestinal health by boosting secretory IgA (sIgA) levels. sIgA is an immunoglobulin (protective antibody) that is found in the digestive tract and in mucosal secretions throughout the body. Maintaining healthy sIgA levels is crucial for supporting immune health, particularly in the GI system where there can be significant exposure to unwanted agents. sIgA acts as the first line of defense against foreign substances in the gut by attaching and neutralizing proteins that are unrecognized by the body. Depleted levels of sIgA are often found in people with low immune response, food intolerance and dysbiosis. Dysbiosis occurs when normally dominant probiotic organisms are outnumbered by commonly out-competed species. In addition to boosting sIgA levels, S. boulardii promotes GI health by competing for space and nutrients against unwanted organisms.

In 53 clinical trials, encompassing 8,475 subjects investigating the safety and efficacy of S. boulardii in pediatric and adult populations, 43 trials (81%) found significant protective efficacy of this probiotic. 3 Supplementation with S. boulardii is an important part of supporting GI health and strengthening the immune system. Each capsule of Saccharomyces boulardii includes 5 billion CFUs of this health-supporting, probiotic yeast.


Healthy Intestinal Barrier Function†

Healthy intestinal barrier function is a key factor in maintaining health. Within the GI tract, tightly packed intestinal cells act as a protective barrier preventing substances such as allergenic compounds, undigested food and toxins from leaking directly into the bloodstream. These represent the major barrier found within the pathway between intestinal epithelial cells. S. boulardii has been shown to improve tight junction structure ensuring that foods and nutrients from the diet are properly absorbed, while blocking the entrance of potentially harmful substances. 4

Blocking Unwanted Microbes†

The intestinal ecosystem is in a state of equilibrium when healthy species of bacteria, or probiotics, are abundant and unwanted microbial species are kept under control. Factors that can upset the balance of a healthy intestinal ecosystem include certain medications, diets high in refined and processed foods, as well as stress and lifestyle factors. S. boulardii has been shown to promote healthy microbial balance by competing against harmful bacteria. 5 Probiotics like S. boulardii can bind and eliminate unwanted organisms during normal probiotic transit and attracts unwanted organisms to the mannose component of its cell wall. 6

Healthy Immune Balance†

In addition to supporting sIgA levels and intestinal barrier function, S. boulardii boosts immune response by supporting healthy white blood cell activity. 7 A double-blind, placebo- controlled trial showed that patients given S. boulardii demonstrated an increase in sIgA levels and a subsequent decrease in C-reactive protein (an indicator of a balanced inflammatory response). The researchers of this study concluded that S. boulardii supports a healthy immune response and protects GI barrier function by maintaining a healthy inflammatory cycle in the GI tract. 8


† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

  1. Buts JP. Twenty-five years of research on Saccharomyces boulardii trophic effects: updates and perspectives.
    Dig Dis Sci 2009; 54(1):15-8.
  2. McFarland LV. Saccharomyces boulardii is not Saccharomyces cerevisiae. Clin Infect Dis 1996;22(1): 200-1.
  3. McFarland LV. Systematic review and meta-analysis of saccharomyces boulardii in adult patients. World J Gastroenterol 2010;16(18): 2202-2222.
  4. Zanello G, Meurens F, Berri M, Salmon H. Saccharomyces boulardii effects on gastrointestinal diseases. Curr Issues Mol Biol 2009; 11(1):47-58.
  5. Buts JP, Corthier G, Delmee M. Saccharomyces boulardii for Clostridium difficile- Associated Enteropathies in Infants. J Ped Gastroenterol Nutr 1993; 16:419-425.
  6. Czerucka D, Piche T, Rampal P. Review article: yeast as probiotics- Saccharomyces boulardii. Aliment Pharmacol Ther 2007; 26(6):767-78.
  7. Caetnao JA, Parames MT, Babo MJ, Santos A, et al. Immunopharmacological effects of Saccahromyces boulardii in healthy human volunteers. Int J Immunopharmacol 1986; 8(3):245-59.
  8. Ozkan TB, Sahin E, Erdemir G, Budak F. Effect of Saccharomyces boulardii in children with acute gastroenteritis and its relationship to the immune response. J Int Med Res 2007; 35(2): 201-12.


Always be sure to speak with your healthcare provider before starting any new nutritional supplement when pregnant or nursing. For children, we recommend speaking with your child's pediatrician regarding proper dosing. Store away from children.


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