Zinc is an essential trace mineral important to many functions of human health. It plays a role in maintaining cellular metabolism and gene expression. Zinc is critical to a diverse group of physiological processes, such as immune function, insulin signaling, tissue repair, vision and neuro-transmission. It is second only to iron in worldwide incidence of deficiency, impacting 2 billion people in developing nations. Due to the wide range of functions regulated by zinc, deficiency, or even marginal deficiency, can have serious health implications.
Zinc is fundamental to the activity of over 100 enzymes and supports immune function, protein synthesis, tissue growth, DNA synthesis and cell division. During pregnancy, infancy and childhood, the body needs zinc for proper growth and development. Zinc also helps tissue repair and is important for adequate functioning of the senses of taste and smell. Daily intake of zinc is necessary to maintain adequate levels within the body because the body has no specialized zinc storage system.
The importance of bioavailability is obvious. If consuming a zinc supplement has little effect on improving the body’s zinc balance, there is no reason to ingest it. Signs of inferior mineral supplements include the use of cheap, poorly absorbed, rocksalt minerals. This product is formulated with the superior amino acid chelate form, zinc glycinate, which does not ionize in the gut and therefore is not impacted by dietary factors and is absorbed at a higher rate than those formulated with zinc salt forms (See Figure 1).
Comparison studies have shown significantly superior absorption of mineral chelates compared to other mineral forms.
- Chelated zinc is 230% better absorbed than zinc sulfate
- Chelated zinc is 390% better absorbed than zinc oxide
- Chelated zinc offers greater protection from interfering dietary factors
Mild to moderate zinc deficiency impacts immune function by slowing down the activity of macrophages, neutrophils, natural killer cells, and complement activity. Individuals with low zinc levels have shown below- normal immune activity that can be corrected by zinc supplementation. Low zinc status has been associated with increased risk of immune challenges that benefit from improving zinc levels.
Zinc plays a role in maintaining the integrity of skin and mucosal membranes. Patients with skin weakness have been observed to have abnormal zinc metabolism and low serum zinc levels. Many clinicians have used zinc to benefit patients with thin, fragile skin.
Researchers have demonstrated that both zinc and antioxidants support eye health in those with age-related loss of visual acuity and general visual decline, by preventing free radical cellular damage in the retina. One population-based cohort study suggests that high dietary intake of zinc, as well as beta carotene, vitamin C and vitamin E, was associated with added support for eye health in elderly subjects.
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Sandstead HH. Understanding zinc: recent observations and interpretations. J Lab Clin Med 1994;124:322-7.
- Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2001.
- Solomons NW. Mild human zinc deficiency produces an imbalance between cell-mediated and humoral immunity. Nutr Rev 1998;56:27-8.
- Prasad AS. Zinc: an overview. Nutrition 1995;11:93-9.
- Heyneman CA. Zinc deficiency and taste disorders. Ann Pharmacother 1996;30:186-7.
- Simmer K, Thompson RP. Zinc in the fetus and newborn. Acta Paediatr Scand Suppl 1985;319:158-63.
- Fabris N, Mocchegiani E. Zinc, human diseases and aging. Aging (Milano) 1995;7:77-93.
- Maret W, Sandstead HH. Zinc requirements and the risks and benefits of zinc supplementation. J Trace Elem Med Biol 2006;20:3-18.
- Prasad AS, Beck FW, Grabowski SM, Kaplan J, Mathog RH. Zinc deficiency: changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in noncancer subjects. Proc Assoc Am Physicians 1997;109:68-77.
- Rink L, Gabriel P. Zinc and the immune system. Proc Nutr Soc 2000;59:541-52.
- Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998;68:447S-63S.
- Wintergerst ES, Maggini S, Hornig DH. Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab 2007;51:301-23.
- Prasad AS. Effects of zinc deficiency on Th1 and Th2 cytokine shifts. J Infect Dis 2000;182 (Suppl):S62 8.
- Bahl R, Bhandari N, Hambidge KM, Bhan MK. Plasma zinc as a predictor of diarrheal and respiratory morbidity in children in an urban slum setting. Am J Clin Nutr 1998;68 (2 Suppl):414S-7S.
- Brooks WA, Santosham M, Naheed A, Goswami D, Wahed MA, Diener-West M, et al. Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial. Lancet 2005;366:999-1004.
- Meydani SN, Barnett JB, Dallal GE, Fine BC, Jacques PF, Leka LS, et al. Serum zinc and pneumonia in nursing home elderly. Am J Clin Nutr 2007;86:1167-73.
- Black RE. Zinc deficiency, infectious disease and mortality in the developing world. J Nutr 2003;133:1485S-9S.
- Lansdown AB, Mirastschijski U, Stubbs N, Scanlon E, Agren MS. Zinc in wound healing: theoretical, experimental, and clinical aspects. Wound Repair Regen 2007;15:2-16.
- Anderson I. Zinc as an aid to healing. Nurs Times 1995;91:68, 70.
- Evans JR. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database Syst Rev 2006;(2):CD000254.
- Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of highdose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001;119:1417-36.
- Van Leeuwen R, Boekhoorn S, Vingerling JR, Witteman JC, Klaver CC, Hofman A, et al. Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA 2005;294:3101-7.
Always be sure to speak with your healthcare provider before starting any new nutritional supplement when pregnant or nursing. For children, we recommend speaking with your child's pediatrician regarding proper dosing. Store away from children.